This information is for healthcare professionals only.
Information for health and care professionals
The PRINCIPLE Trial has now closed recruitment. Thank you to all of the participating GP sites who helped to recruit and follow-up with many of the PRINCIPLE participants.
If you are a green-lit site, we will be contacting you about a formal site-close that we will be conducting remotely. Please click this link to download the zipped folder of the Investigator Site File.
More information and alternative ways to download the Investigator Site File can be found in out Site Close Out section.
Thank you for participating in COVID-19 research!
These resources aim to support all health professionals working with or interested in the PRINCIPLE Trial.
Resources are divided according to medical centre type, including GP surgeries, secondary care, care homes, NHS Trusts, and 111 Hubs.
Please navigate to where best suits your health care centre type. If you have any questions about this please feel free to contact the PRINCIPLE Trial team - email@example.com
The Chief Medical Officers of England, Wales, Scotland and Northern Ireland, and the NHS Medical Director, have written to all doctors strongly encouraging participation in the national randomised trials in COVID-19, of which PRINCIPLE is one.
Open letter: The importance of COVID-19 clinical trials
Open letter: Recruiting patients for clinical trials for COVID-19 therapeutics
PRINCIPLE: protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk
BMJ Open 2021;11:e046799. doi: 10.1136/bmjopen-2020-046799
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