The PRINCIPLE Trial has finished recruitment and analysis. We will continue to share all the results and news on this website.
A massive thank you to all our participants and colleagues for their contribution to this incredible research.
For a comprehensive look into our trial please read our guide
If you have any questions please contact us.
PRINCIPLE: Helping to find treatments for COVID-19 from home
PRINCIPLE is a UK-wide clinical study from the University of Oxford to find COVID-19 treatments for recovery at home.
We are looking for medicines that can help people with COVID-19 symptoms get better quickly and stop them needing to go to hospital. PRINCIPLE recruited participants through this website and also through GP practices across the UK.
PRINCIPLE was open to all with ongoing symptoms of COVID-19, regardless of vaccination status.
11,768
PARTICIPANTS RECRUITED
847
RECRUITMENT SITES
7
MEDICATIONS STUDIED
Results and Publications:
PRINCIPLE has already made some important findings on the effectiveness of COVID-19 treatments. If you would like to find out more about the some of the results and findings so far from PRINCIPLE please use the link below.
Community outreach and partnerships:
The PRINCIPLE team have partnered with a wide range of community groups and organisations across the UK to help raise awareness and increase inclusivity in the trial. To find out more about this work or see some of our translation resources please use the link below.
Or contact us directly:
principle@phc.ox.ac.uk
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PRINCIPLE is funded by UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health and Care Research.
EudraCT number: 2020-001209-22 • ISRCTN registry: ISRCTN86534580 • REC number: 20/SC/0158 • IRAS number: 281958