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An image of lungs, a chemical structure diagram of budesonide, and a budesonide inhaler.

Asthma drug budesonide shortens recovery time in non-hospitalised patients with COVID-19

Inhaled budesonide, a common corticosteroid, is the first widely available, inexpensive drug found to shorten recovery times in COVID-19 patients aged over 50 who are treated at home and in other community settings, reports the PRINCIPLE trial in 1,779 participants. The drug is now available to treat COVID-19 on a case-by-case basis in UK primary care.

Latest research news and updates

A telephone ringing

PRINCIPLE trial 'highly commended' for innovative use of health data

The PRINCIPLE trial has been highly commended at the Health Data Research UK Awards for the way in which patient data is utilised so participants are contacted about the trial soon after receiving a positive test result.

: IVERMECTIN in white bottle packaging with scattered pills. Isolated on blue background. Horizontal shot. Copy space.

Ivermectin to be investigated in adults aged 18+ as a possible treatment for COVID-19 in the PRINCIPLE trial

From today, ivermectin is being investigated in the UK as part of the Platform Randomised Trial of Treatments in the Community for Epidemic and Pandemic Illnesses (PRINCIPLE), the world’s largest clinical trial of possible COVID-19 treatments for recovery at home and in other non-hospital settings.

A bottle of favipiravir pills, 200mg

Favipiravir to be investigated as a possible COVID-19 treatment for at-home recovery in the PRINCIPLE trial

Could the antiviral favipiravir help transform COVID-19 into an illness that can be successfully treated by general practitioners?

A graphic of coronavirus and colchcine blister pack with a chemical structure.

PRINCIPLE COVID-19 treatments trial widens to under 50s and adds colchicine

From today, the UK’s national priority platform trial of COVID-19 treatments for recovery at home launches its investigation of the gout drug colchicine, and expands for the first time to include adults of any age.

A lady at home takes a pill with a glass of water.

Azithromycin and doxycycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial

Update from the Chief Investigators of the Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE), 25 January 2021

A railway sign saying "Leicester"

De Montford University Leicester students to support PRINCIPLE trial recruitment

Students from De Montfort University Leicester (DMU) are the first in the country to help drive the PRINCIPLE clinical study to find Covid-19 treatments for the over 50’s that can help speed up recovery.

A white turbohaler on a blue background with a brown screw.

Inhaled corticosteroids to be investigated as a possible treatment for Covid-19 in national PRINCIPLE Trial

Inhaled budesonide is an inexpensive, safe and commonly prescribed treatment for asthma and COPD. It is the fourth medication to be tested in PRINCIPLE.

A bag in a pharmacy.

Two major pharmacy chains join PRINCIPLE Trial

Two of the UK’s largest pharmacy chains, LloydsPharmacy and Well Pharmacy, are tasking their branches with helping to find suitable patients for the PRINCIPLE Trial of Covid-19 treatments.

Neasden Temple, London.

Britain’s most influential Hindu temple spreads awareness of the PRINCIPLE trial among Indian community

Europe’s BAPS Swaminarayan Sanstha, the largest Hindu temple outside of India, is supporting their community during the coronavirus pandemic by spreading awareness of the PRINCIPLE trial of Covid-19 treatments.

A senior woman's hand holding medication with a glass of water.

PRINCIPLE Trial of COVID-19 treatments recruits 1000th participant

More than 1000 people across the UK have signed-up to take part in the UK-wide PRINCIPLE Trial of potential community-based treatments for COVID-19, led by Oxford University.

An image of Professor Mahendra Patel

PRINCIPLE Trial to strengthen Black, Asian and minority ethnic community participation

Professor Mahendra G Patel, University of Bradford, joins PRINCIPLE Trial as National Black, Asian and minority ethnic Community and Pharmacy Lead

COVID Symptom Tracker and PRINCIPLE

PRINCIPLE and ZOE partner to widen access to trial

Oxford University and the COVID Symptom Study app are joining forces to widen access to the PRINCIPLE trial of potential treatments for COVID-19.

PRINCIPLE trial suspends hydroxychloroquine, continues with focus on azithromycin and other drugs

PRINCIPLE Trial calls on UK primary care to support patient recruitment

The Co-Chief Investigators of the PRINCIPLE Trial, Professor Chris Butler and Professor Richard Hobbs, write an open letter to health professionals across UK primary care calling on their support, so those who are still contracting COVID-19 are given the opportunity to join the trial.

PRINCIPLE trial rolled out across UK homes and communities

National priority COVID-19 trial recruits first patients

Researchers from Oxford University are now enrolling participants into PRINCIPLE, the first clinical trial of potential COVID-19 treatments to take place in GP practices.

Letter from Chief Medical Officers encourages participation in COVID-19 trials, including PRINCIPLE

GP practices urged to join COVID-19 research

The Nuffield Department of Primary Care Health Sciences at the University of Oxford and the Royal College of General Practitioners (RCGP) have joined forces with clinical system supplier EMIS Health to urgently recruit as many GP practices as possible for COVID-19 research.