The potential use of ivermectin as a treatment for COVID-19 has been a topic of intense debate and discussion throughout the pandemic. As one of the largest and most rigorous trials to investigate ivermectin's effectiveness in community settings, the PRINCIPLE trial's findings regarding this repurposed drug are of interest to a lot of people.

In this section, we look into the specific details of the ivermectin arm of the PRINCIPLE trial, including the methodology, participant characteristics, and the comprehensive results obtained after following participants for up to 12 months post-treatment.

We aim to provide a balanced and transparent overview of the trial's conclusions, addressing key questions and concerns raised by both proponents and skeptics of ivermectin's use for COVID-19 and to contribute to an evidence-based understanding of its potential role in the management of COVID-19 in non-hospital settings.