Thank you for your interest in the PRINCIPLE Trial. PRINCIPLE is now paused to new registrations.

Your interest and contribution to the PRINCIPLE trial is greatly valued. Thank you for helping us in our search to evaluate if treatment administered early in the course of the COVID-19 illness can help those at higher risk recover quickly, without the need for hospital admission.

PRINCIPLE: Helping to find treatments for COVID-19 from home

PRINCIPLE is a UK-wide clinical study from the University of Oxford to find COVID-19 treatments for recovery at home.

We are looking for medicines that can help people with COVID-19 symptoms get better quickly and stop them needing to go to hospital. PRINCIPLE recruited participants through this website and also through GP practices across the UK.

PRINCIPLE was open to all with ongoing symptoms of COVID-19, regardless of vaccination status.

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PARTICIPANTS RECRUITED

A huge thank you to all of the thousands who have volunteered. Your contribution to the PRINCIPLE trial is greatly valued. Thank you for helping us in our search to evaluate if treatment administered early in the course of the COVID-19 illness can help those at higher risk recover quickly, without the need for hospital admission.

Who is eligible to join PRINCIPLE:

You are currently experiencing COVID-19 symptoms for 14 days or less.

AND: You have had a positive test for COVID-19 in the last 14 days

AND: You are aged 18 or over

All current treatment arms being investigated are fully recruited:

Sign-Up has now been paused

PRINCIPLE has now paused all current arms as we have reached our required number of participants. If you are already on the trial please continue to complete the process and diaries. The trial team and your own GP will still be available for you to contact throughout.

Results and Publications:

PRINCIPLE has already made some important findings on the effectiveness of COVID-19 treatments. If you would like to find out more about the some of the results and findings so far from PRINCIPLE please use the link below.

Results and Publications

Community outreach and partnerships:

The PRINCIPLE team have partnered with a wide range of community groups and organisations across the UK to help raise awareness and increase inclusivity in the trial. To find out more about this work or see some of our translation resources please use the link below.

Community Outreach