The PRINCIPLE Trial is now Closed.
A massive thank you to all our participants and colleagues for their contribution to this incredible research. YOUR INTEREST TO THE PRINCIPLE TRIAL IS GREATLY VALUED.
We will continue to update our website with any news or publications from this study. If you have any questions please contact us
PRINCIPLE: Helping to find treatments for COVID-19 from home
PRINCIPLE is a UK-wide clinical study from the University of Oxford to find COVID-19 treatments for recovery at home.
We are looking for medicines that can help people with COVID-19 symptoms get better quickly and stop them needing to go to hospital. PRINCIPLE recruited participants through this website and also through GP practices across the UK.
PRINCIPLE was open to all with ongoing symptoms of COVID-19, regardless of vaccination status.
A huge thank you to all of the thousands who have volunteered. Your contribution to the PRINCIPLE trial is greatly valued. Thank you for helping us in our search to evaluate if treatment administered early in the course of the COVID-19 illness can help those at higher risk recover quickly, without the need for hospital admission.
Sign-Up has now closed
PRINCIPLE has now closed as we have reached our required number of participants and there will be no further trial medications included to this study. If you are already on the trial please continue to complete you follow-ups, including our 3, 6, and 12 month questionnaires. The trial team and your own GP will still be available for you to contact throughout.
Results and Publications:
PRINCIPLE has already made some important findings on the effectiveness of COVID-19 treatments. If you would like to find out more about the some of the results and findings so far from PRINCIPLE please use the link below.
Community outreach and partnerships:
The PRINCIPLE team have partnered with a wide range of community groups and organisations across the UK to help raise awareness and increase inclusivity in the trial. To find out more about this work or see some of our translation resources please use the link below.
Please share the PRINCIPLE trial:
PRINCIPLE is funded by UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health and Care Research.
EudraCT number: 2020-001209-22 • ISRCTN registry: ISRCTN86534580 • REC number: 20/SC/0158 • IRAS number: 281958